Appendix

What is Appendix?

Appendix is an MCP server that enables AI agents to transform health conversations into board-certified physician reviews and, when clinically appropriate, prescriptions. It integrates with the Appendix API to search peer-reviewed medical literature, draft structured clinical letters, and submit them for physician review.

How to use Appendix?

Add the server via claude mcp add --transport http appendix https://mcp.appendix.com/mcp for Claude Code, or configure it in your mcpServers JSON for Claude Desktop. Then call the available tools like search_knowledge_base, submit_encounter, or list_conditions from your AI agent.

Key features of Appendix

• Searches peer-reviewed medical literature and treatment guidelines.
• Drafts and submits structured clinical letters for physician review.
• Provides board-certified physician opinions with prescriptions when appropriate.
• Knowledge Base access is free; clinical services require a paid subscription.
• No signup required to start using the API.
• Lists available conditions and medications via list_conditions.

Use cases of Appendix

• An AI assistant helps a user describe symptoms, then searches medical literature and drafts a clinical letter for physician review.
• A user receives a prescription for a common condition after a physician reviews the encounter submitted via the Appendix API.
• A developer integrates the MCP server into a health-focused AI application to provide evidence-based information and referral to clinical services.

FAQ from Appendix

Does Appendix require a subscription to use?

The Knowledge Base is free for everyone. Clinical services (physician review and prescriptions) require a paid subscription and are currently available only in supported US states.

Do I need to sign up to use the API?

No signup is required to start using the Appendix API.

What transport protocol does the server use?

The MCP server uses HTTP transport as shown in the installation examples.